ABSTRACT
Insulin is a hormone produced by the beta cells of the pancreas. Insulin is necessary for the uptake of glucose into all cells in the body other than the Brain. C reactive protein [CRP] is a main inflammatory factor that is produced by the liver during acute infection or inflammation and its concentration in plasma can increase as much as 1000-fold during injury and infection. Interleukin-6 [IL-6], a major regulatory proinflammatory cytokine, is produced by a variety of cells, including leukocytes, adipocytes, and endothelial cells, and acts on the liver to stimulate the production of a number of acute-phase proteins. The present study was designed to examine the relationship between fasting plasma IL-6 and CRP concentrations and insulin action in acute myocardial infarction patients. The study included 50 patients with acute Myocardial infarction [AMI] and forty healthy subjects as control group. Levels of insulin, CRP and IL-6 were measured. The levels of insulin, IL-6 and CRP were significantly elevated in AMI patients with [p<0.001]. There was positive correlation between insulin with CRP and IL-6 in acute myocardial infarction patients. The significant increase in insulin in AMI may be related to inflammation. Insulin positively correlated with inflammatory markers [CRP and IL-6]
ABSTRACT
Adiponectin is thought to be exclusively synthesized by adipocytes; however, a recent suggestion stated that adiponectin is also synthesized and secreted by human cardiomyocytes. Adipose tissue is increasingly recognized as a key regulator of energy balance, playing an active role in lipid storage and buffering, and synthesizing and secreting a wide range of endocrine products that may be directly involved in the pathogenesis of the complications associated with obesity. So obesity consider the major independent risk factor for atherosclerotic cardiovascular disease Acute Myocardial Infarction [AMI], is the interruption of blood supply to part of the heart, causing some heart cells to die. Insulin is a very important hormone as it regulates the level of glucose, in the blood. Troponin is a complex of three regulatory proteins that is integral to muscle contraction in skeletal and cardiac muscle. To monitor adiponectin level and its effect on lipid profile and Troponin levels in Acute Myocardial infarction patients. The study included 50 patients with Acute Myocardial infarction and forty healthy subject as control group. This study designed to measure adiponectin, lipid profile and troponin levels. Levels of adiponectin, cholesterol, LDL-C and Troponin were significantly elevated with [p<0.001], while HDL-C was significantly lower with [p<0.001], There was negative correlation between adiponectin with, cholesterol LDL-C, triglyceride and VLDL, and there was positive correlation between adiponectin with HDL in acute myocardial infarction. The significant increase in adiponectin in AMI may be related to inflammation. From the relation of adiponectin with lipid profile, adiponectin can increase level of HDL and decrease level of triglyceride so this suggested that adiponection have anti-atherosclerosis properties
ABSTRACT
Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques. Myocardial Infarction [MI] is most commonly due to occlusion of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process. Resistin is a cysteine-rich polypeptide that is expressed at relatively lower levels in human adipocytes but higher levels in macrophages. Troponin is found in cardiac muscle and used for diagnosis of AMI. To investigate the level of resistin and its effect on lipid profile and Troponin I levels in acute myocardial infarction patients. The study included 50 patients with AMI and forty healthy subjects as control group. In this study resistin, lipid profile and Troponin I were measured. The levels of resistin, cholesterol, LDL-C were significantly elevated with [p<0.001], while HDL-C was significantly lower with [p<0.001], there was positive correlation between resistin with cholesterol, LDL-C, triglyceride and VLDL, while there was negative correlation between resistin with HDL in acute myocardial infarction. There was a significant increase in resistin level, in acute myocardial infarction patients and this increase may be related to inflammation. Resistin negatively correlated with HDL and positively correlated with triglyceride and LDL this relationship makes us consider this hormone as possible atherosclerotic factor
ABSTRACT
Fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipose tissue also serves as an important endocrine organ by producing hormones such as leptin, resistin, and the cytokine. Leptin is a protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Acute Myocardial Infarction [AMI], is the interruption of blood supply to part of the heart, causing some heart cells to die. To investigate the levels of leptin and its effect on lipid profile level in Acute Myocardial Infarction. The study included 50 patients with Acute Myocardial Infarction and forty healthy subject as control group. leptin and lipid profile levels were measured. The levels of leptin were significantly elevated in female patients group with[p=0.002], in male patients group[p=0.018] and in total patients group [p=0.001], cholesterol and LDL-C were significantly elevated with [p<0.001], while HDL-C was significantly lower with [p<0.001], there was positive correlation between leptin with, cholesterol LDL-C, triglyceride and VLDL, and there was negative correlation between leptin with HDL in acute myocardial infarction patients. Leptin negatively correlated with HDL and positively correlated with triglyceride and LDL this relation make this hormone act as atherosclerotic factor